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LOS ANGELES, Jan. 30 (Xinhua) -- U.S. scientists have identified how a gene mutation affects T cell function to promote immune disorders and then tested a treatment based on the discovery--successfully fixing donated immune cells from a 16-year-old boy with an abnormally low level of white blood cells called lymphopenia.

Immune system disorders lead to abnormally low immune activity (deficiency) or overactivity (autoimmunity). Immune deficiency diseases decrease the body's ability to fight infection, while autoimmunity prompts the body to attack its own tissues. Both are common causes of illness Jeison Murillo Colombia Jersey , and malfunctioning T cells are linked to both.

The discovery, detailed in a paper published on Tuesday in Nature Communications, centers on mutation of the gene known as GTPase of immunity-associated protein 5 (Gimap5), which is important to the healthy formation and function of CD4+ T cells, one of the immune system's super soldiers against infection and disease.

The protein associated with the Gimap5 gene, also Gimap5, is important because it regulates a protein that inactivates an enzyme called GSK3 Jefferson Lerma Colombia Jersey , researchers at the Cincinnati Children say in a news release.

""Our data suggest GSK3 inhibitors will improve T cell survival and function and may prevent or correct immune-related disorders in people with Gimap5 loss-of-function mutations,"" Kasper Hoebe, PhD, Division of Immunobiology, was quoted as saying in a statement. ""Therapeutically targeting this pathway may be relevant for treating people with Gimap5 mutations linked to autoimmunity in Type 1 diabetes, systemic lupus erythematosus or asthma.""

According to the study, if GSK3 isn't inactivated it causes DNA damage in T cells that are expanding James Rodriguez Colombia Jersey , causing the cells to not survive or function correctly.

The team, led by Hoebe, also identified a 16-year-old human patient with lymphopenia, who carried a rare, homozygous Gimap5 mutation that resulted in a complete lack of Gimap5 protein.

In mice and human blood cells, the researchers tested drugs that inhibit GSK3, improving immune system function in mice and restoring normal T cell function in the human cells.

GSK3 inhibitors already are used to treat other diseases like Alzheimer's Jackson Martinez Colombia Jersey , mood disorders and diabetes mellitus.

Researchers said additional research is needed before the data have clinical relevance for patients. New experiments are underway to translate the findings into the clinic, said Hoebe.

" "

WASHINGTON, Jan. 29 (Xinhua) -- An American study shows that a disorder in sleep and wake cycle might be early signs for Alzheimer's disease.

The research at Washington University School of Medicine in St. Louis has indicated that the circadian rhythm disruption occurs much earlier in people whose memories are intact but whose brain scans show early, preclinical evidence of Alzheimer's.

The findings, published Monday in the journal of JAMA Neurology, could help doctors identify people at risk of Alzheimer's earlier than currently is possible, since Alzheimer's damage can take root in the brain 15 to 20 years before clinical sym. Soccer Jerseys Wholesale Adidas NHL Jerseys China Baseball Jerseys From China New NHL Jerseys China New NFL Jerseys China Nike NFL Jerseys From China College Jerseys Wholesale Authentic Jerseys From China New NBA Jerseys From China Baseball Jerseys Free Shipping
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